Peculiarities of blood flow in the uterine arteries, factors of angiogenesis, hormonal profile and their relationships in pregnant women with hypertension

The objective: to assess and establish the relationships between Doppler blood flow indicators in uterine arteries, angiogenesis factors hormones of mother-placenta-fetus system pregnant women with arterial hypertension I-II degree.Materials methods. A prospective study 88 at 11–12 weeks gestation was carried out: 61 chronic (CH) I–II degree (main group) 27 healthy physiological pregnancy (control group). All patients have been examined: left right arteries – pulsation index (PI), resistance (IR) systolic-diastolic ratio (SDR). Chorionic gonadotropin (HCG), progesterone (PG), estradiol (E) indices (placental growth factor (PlGF) as a pro-angiogenic factor) placental-soluble fms-like tyrosine kinase (sFlt-1) an anti-angiogenic sFlt-1/PlGF) were determined blood. Statistical analysis performed using program “STATISTICA 13”.Results. There no statistically significant difference SDR IP groups. PI values artery main group significantly higher than indicator (1.73 (1.65; 1.8) units versus 1.33 (1.1; 1.49) units, respectively). CAH also differed from those course (1.7 (1.66; 1.79) 1.35 (1.22; 1.51) correlation markers hormonal profile has not established. In CAH, inverse relationship observed PlGF (mean strength R=-0.34 for R= -0.41 artery), respectively, sFlt-1/PlGF direct (average R=+ 0.37 R=+0.43 artery). childbirth, value correlated (direct relationship) level (feedback). had ratio. decreases, while value, on contrary, increases.Conclusions. differences SDS IR without found compared CAH. is accompanied by shift balance pro- factors, evidenced increase sFlt-1 against background decrease level, well corresponding are correlations Nevertheless, correlate (feedback) This indicates presence disorders this contingent I trimester pregnancy.